abstract：:The therapeutic landscape for renal cell carcinoma (RCC) has changed drastically over the past several years with the emergence of molecularly targeted therapies. With previous prognostic and predictive tools based on studies of patients treated with cytokine therapies, confirmation of these prior methods and discover...

journal_title：Current oncology reports

authors： Cowey CL,Rathmell WK

更新日期：2009-03-01 00:00:00

abstract：:There is no clear consensus regarding the most effective management of poor responders to neoadjuvant chemotherapy. Intensifying or changing primary systemic treatment has not been shown to offer any benefit. There is a paucity of trials testing the utility of adjuvant chemotherapy in this setting. Adjuvant hormonal t...

journal_title：Current oncology reports

authors： Wesolowski R,Budd GT

更新日期：2009-01-01 00:00:00

abstract：:Notch signaling plays crucial roles in many developmental pathways, with Notch mutations linked to several developmental disorders. Because many pediatric malignancies arise from dysregulated development, roles for Notch signaling in these cancers are to be expected. Evidence to support this is now emerging as the Not...

journal_title：Current oncology reports

authors： Zweidler-McKay PA

更新日期：2008-11-01 00:00:00

abstract：:With our understanding of human papillomavirus (HPV) and cervical cancer, the availability of HPV testing, and the known limitations of cervical cytology, it is time to reassess cervical cancer screening technologies. This article reviews recent randomized trials comparing primary HPV testing with cervical cytology in...

journal_title：Current oncology reports

authors： Runowicz CD,Garozzo S

更新日期：2008-11-01 00:00:00

abstract：:The treatment of non-Hodgkin lymphoma (NHL) has changed dramatically since the introduction of rituximab, a monoclonal antibody that binds to the B-cell transmembrane protein CD20 and causes lysis of the lymphoma cells. Since then, a number of additional antibodies have been tested against other B-cell targets, result...

journal_title：Current oncology reports

authors： Sikder MA,Friedberg JW

更新日期：2008-09-01 00:00:00

abstract：:Chordomas and chondrosarcomas of the skull base are rare, indolent tumors with a natural history of locally invading their surroundings. Safe, maximal resection is the mainstay of treatment, followed by adjuvant radiation therapy. Even with multimodality therapy, local recurrence remains the most common failure patter...

journal_title：Current oncology reports

authors： Nguyen QN,Chang EL

更新日期：2008-07-01 00:00:00

abstract：:Radiation plays an important role in the multimodal management of tumors of the gastrointestinal (GI) system. Intensity-modulated radiation therapy (IMRT) is a technological development that was introduced to limit the acute and late toxicities commonly associated with conventional radiation therapy. Numerous preclini...

journal_title：Current oncology reports

authors： Meyer JJ,Czito BG,Willett CG

更新日期：2008-05-01 00:00:00

abstract：:Overall survival for patients with squamous cell carcinoma of the head and neck (SCCHN) has not improved appreciably over the past few decades. Because standard treatments have not controlled this disease with sufficiently high success rates, novel therapeutic approaches, such as immunotherapy, are under investigation...

journal_title：Current oncology reports

authors： Leibowitz MS,Nayak JV,Ferris RL

更新日期：2008-03-01 00:00:00

abstract：:Mutations in the cancer susceptibility genes BRCA1 and BRCA2 are associated with significantly increased risks of breast and ovarian cancer. Fortunately, effective strategies are available to reduce these risks, including genetic testing, which is an important consideration in determining management of patients with a...

journal_title：Current oncology reports

authors： Gulati AP,Domchek SM

更新日期：2008-01-01 00:00:00

abstract：:Pediatric medicine is moving toward a greater appreciation that the delivery of quality medical care involves a partnership including the health care team, the child, and the family. Pediatric medicine now emphasizes the importance of information exchange among these groups. This paper discusses two models for communi...

journal_title：Current oncology reports

authors： Weidner NJ

更新日期：2007-11-01 00:00:00

abstract：:Cancer risk has become a significant research topic due to an increase in statistical risk models built to predict cancer incidence or mortality. Over the past 3 years, 15 models on the development of different types of cancer, including breast, colorectal, prostate, gastric, lung, ovarian, pancreatic, testicular, and...

journal_title：Current oncology reports

authors： Johnson CM,Smolenski D

更新日期：2007-11-01 00:00:00

abstract：:Brain metastases seem to be an almost inevitable complication in patients with metastatic melanoma. Except for the rare patients who can undergo successful surgical resection of brain metastases, current management strategies do not appear adequate and result in a poor outcome (median survival, 2-4 months). In recent ...

journal_title：Current oncology reports

authors： Majer M,Samlowski WE

更新日期：2007-09-01 00:00:00

abstract：:The result of a lung cancer screening program should be fewer lung cancer-specific deaths in the screened population. Studies evaluating chest imaging as a screening tool for lung cancer have not shown a reduction in lung cancer-specific mortality to date. The ability of institutions using chest imaging to meet the cr...

journal_title：Current oncology reports

authors： Mazzone PJ,Mekhail T

更新日期：2007-07-01 00:00:00

abstract：:Following resection of hepatic colorectal metastases, there are few criteria for predicting which patients have more aggressive disease and are, therefore, more likely to experience recurrence and reduced survival. Traditionally, primary tumor stage, preoperative carcinoembryonic antigen level, time from primary tumor...

journal_title：Current oncology reports

authors： Pawlik TM,Choti MA

更新日期：2007-05-01 00:00:00

abstract：:Management of tumors of the salivary glands requires a detailed understanding of the anatomy and pathologic processes affecting these glands. Salivary glands give rise to benign and malignant neoplasms and are affected by a variety of systemic diseases. CT remains the most common primary imaging study; magnetic resona...

journal_title：Current oncology reports

authors： Scianna JM,Petruzzelli GJ

更新日期：2007-03-01 00:00:00

abstract：:Glioblastoma multiforme (GBM) is the most common central nervous system malignancy. It is rapidly progressive with rare opportunity for cure. After three decades of laboratory and clinical research, a newly evolved chemoradiotherapy approach using the alkylating agent temozolomide during and after radiotherapy has res...

journal_title：Current oncology reports

authors： Robins HI,Chang S,Butowski N,Mehta M

更新日期：2007-01-01 00:00:00

abstract：:Recent advances in molecular biology have enhanced our understanding of the pathogenesis of brain tumors, particularly in children. The use of molecular diagnostic tools is quickly becoming a standard component in the diagnosis and classification of brain tumors in children, in addition to providing insight leading to...

journal_title：Current oncology reports

authors： Ullrich NJ,Pomeroy SL

更新日期：2006-11-01 00:00:00

abstract：:Lymphoma is the third most common cancer in children and adolescents. Non-Hodgkin's lymphomas comprise a heterogeneous group of tumors with distinct pathologic and clinical characteristics. Over the past three decades, significant advancements have been made in the molecular characterization of these disorders. With t...

journal_title：Current oncology reports

authors： Shukla NN,Trippett TM

更新日期：2006-09-01 00:00:00

abstract：:Primary and metastatic spinal mesenchymal tumors are uncommon lesions. Surgical management of these tumors remains a challenge. En bloc wide resection provides the best chance for local tumor control and long-term survival. However, limitations to this technique include technical considerations (including neurovascula...

journal_title：Current oncology reports

authors： Mody MG,Rao G,Rhines LD

更新日期：2006-07-01 00:00:00

abstract：:Although postoperative chemoradiation has a proven role in the treatment of stage II to III localized rectal cancer, recent trials have demonstrated the role of preoperative chemoradiation. A recent randomized trial has shown that preoperative chemoradiation yields higher rates of local control and sphincter preservat...

journal_title：Current oncology reports

authors： Das P,Crane CH

更新日期：2006-05-01 00:00:00

abstract：:The endothelins (ETs), which include ET-1, ET-2, ET-3, and their receptors ET-A and ET-B, play a major role in tumor growth, proliferation, apoptosis, angiogenesis, and bone metastasis. Atrasentan is a novel and selective inhibitor of ET-1 and ET-A. In vitro and in vivo data show that this oral agent is capable of inh...

journal_title：Current oncology reports

authors： Thakkar SG,Choueiri TK,Garcia JA

更新日期：2006-03-01 00:00:00

abstract：:Postmastectomy radiotherapy continues to be one of the most controversial issues in breast radiotherapy. At the crux of the controversy lies the lack of conclusive studies that specifically address the risk-benefit ratio of postmastectomy radiotherapy for patients at intermediate risk of developing locoregional recurr...

journal_title：Current oncology reports

authors： Sartor CI

更新日期：2006-01-01 00:00:00

abstract：:The utility of lymphatic mapping and sentinel lymph node biopsy in malignancies of the female lower genital tract-- vulvar, vaginal, and cervical cancers--is being explored in multiple centers internationally. For patients with these tumors, lymphatic mapping with sentinel lymph node biopsy holds the promise of increa...

journal_title：Current oncology reports

authors： Frumovitz M,Ramirez PT,Levenback C

更新日期：2005-11-01 00:00:00

abstract：:The search is on for biomarkers for use in the diagnosis, staging, prognosis, and management of patients with melanoma. As with many types of cancer, the hematogenous spread of melanoma is a bad prognostic sign, and many groups have attempted to detect circulating melanoma cells in patients with different stages of me...

journal_title：Current oncology reports

authors： Kounalakis N,Goydos JS

更新日期：2005-09-01 00:00:00

abstract：:For the subgroup of patients with inoperable gastrointestinal stromal tumors, progress has been made by the rapid development and approval of the targeted therapy imatinib mesylate. Small round cell sarcomas (SRCT), such as Ewing/primitive neuroectodermal tumor, desmoplastic SRCT, and rhabdomyosarcoma, are chemotherap...

journal_title：Current oncology reports

authors： Hartmann JT,Patel S

更新日期：2005-07-01 00:00:00

abstract：:New combinations of chemotherapy with radiotherapy for gastrointestinal cancers are showing evidence that improved outcomes may result from toxicity profiles associated with "targeted" systemic radiosensitizing agents. These new agents are also clinically attractive owing to such factors as oral bioavailability and pa...

journal_title：Current oncology reports

authors： Rich TA,Crane C,Lawson JD,Landry J

更新日期：2005-05-01 00:00:00

abstract：:High-risk non-melanoma skin cancer (NMSC) of the head and neck is difficult to manage, given its propensity for regional metastasis, perineural invasion, direct parotid invasion, and bony destruction. Management of these tumors demands awareness of the characteristics contributing to their recurrence. Recent studies e...

journal_title：Current oncology reports

authors： Lai SY,Weber RS

更新日期：2005-03-01 00:00:00

abstract：:Primary intraocular lymphoma (PIOL) is a subset of primary central nervous system lymphoma (PCNSL) in which malignant lymphoid cells invade the retina, vitreous body, or optic nerve head. It is usually a large B-cell non-Hodgkin's lymphoma. PIOL typically presents as a vitritis that is unresponsive to corticosteroid t...

journal_title：Current oncology reports

authors： Kim SK,Chan CC,Wallace DJ

更新日期：2005-01-01 00:00:00

abstract：:Skin cancer is the most common type of cancer in the United States. US incidence of malignant melanoma is increasing faster than any other type of cancer. To minimize increasing morbidity and mortality rates, it is imperative that appropriate screening and early detection of skin cancer become more widespread. All phy...

journal_title：Current oncology reports

authors： Linden KG

更新日期：2004-11-01 00:00:00

abstract：:The evolution of our ability to diagnose and classify lymphomas in an increasingly refined manner has paralleled the development of novel technologic approaches, with contemporary practice dependent upon the harnessing of a plethora of data that include microscopic, immunophenotypic, and genetic information. Although ...

journal_title：Current oncology reports

authors： Bagg A

更新日期：2004-09-01 00:00:00

abstract：:Although gastric cancer is still a worldwide major public health concern, it remains relatively uncommon in the Western countries. Despite improvement in surgical morbidity and mortality, as well as significant advancement of chemotherapy and radiotherapy options, the survival for gastric cancer has not significantly ...

journal_title：Current oncology reports

authors： Phan AT,Ajani JA

更新日期：2004-05-01 00:00:00

abstract：:Cyclin-dependent kinases (CDKs) and their related pathways represent some of the most attractive targets in the development of anticancer therapeutics. Among a variety of CDK inhibitors under development, flavopiridol, UCN-01, CYC202, and BMS-387032 are undergoing clinical evaluation based on evidence of preclinical a...

journal_title：Current oncology reports

authors： Dai Y,Grant S

更新日期：2004-03-01 00:00:00

abstract：:The success of the angiogenesis inhibitor bevacizumab, the vascular endothelial growth factor antagonist that was recently shown to significantly improve the survival of patients with metastatic colon cancer when administered in combination with conventional chemotherapy, has provided proof of principle in clinical tr...

journal_title：Current oncology reports

authors： Moses MA,Harper J,Fernández CA

更新日期：2004-01-01 00:00:00

abstract：:The establishment of the Intergroup Rhabdomyosarcoma Study (IRS) Committee in 1972 by three extant American pediatric cooperative groups initiated five generations of studies in the multidisciplinary treatment of soft-tissue sarcomas. Taking the lead from the use of vincristine, actinomycin-D, and cyclophosphamide (VA...

journal_title：Current oncology reports

authors： Ruymann FB

更新日期：2003-11-01 00:00:00

abstract：:Gastrointestinal stromal tumors (GISTs), the most common mesenchymal tumors of the intestinal tract, are characterized by the expression of KIT, also known as CD117. Increasingly, primary tumors from novel sites are being described. The KIT gene is commonly mutated, causing constitutive activation of the protein and a...

journal_title：Current oncology reports

authors： von Mehren M

更新日期：2003-07-01 00:00:00

abstract：:Chemotherapy was traditionally perceived to be ineffective for prostate cancer and was only administered to patients with symptomatic hormone-refractory disease. Although previous reviews have confirmed this belief, recent studies have demonstrated significant antitumor activity with chemotherapy regimens. This articl...

journal_title：Current oncology reports

authors： Petrylak DP

更新日期：2003-05-01 00:00:00

abstract：:Intensity-modulated radiotherapy (IMRT) is the next evolutionary step of three-dimensional conformal radiotherapy (3-DCRT). IMRT plans are generated with computer-optimized nonuniform radiation beam intensities incident on a target or patient. The dose distributions in IMRT show significantly higher conformality compa...

journal_title：Current oncology reports

authors： Peñagarícano JA,Papanikolaou N

更新日期：2003-03-01 00:00:00

abstract：:Osteoporosis is a disease that causes substantial morbidity and mortality for which preventive therapy is available. Women with breast cancer are at increased risk for osteoporosis for several reasons, including premature ovarian failure as a result of treatment, direct effects of chemotherapy, and effects of the brea...

journal_title：Current oncology reports

authors： Mincey BA

更新日期：2003-01-01 00:00:00

abstract：:Lung cancer is the most common cause of cancer death worldwide. The overall 5-year survival rate remains disappointing at 14% or less. Several clinician- and community-based interventions show promise for reducing lung cancer incidence through prevention and smoking cessation. However, long-term heavy smokers retain a...

journal_title：Current oncology reports

authors： McWilliams A,Lam S

更新日期：2002-11-01 00:00:00

abstract：:Options for treatment of poor-prognosis or relapsed acute myeloid leukemia (AML) remain limited. Gemtuzumab ozogamicin (Mylotarg, Wyeth-Ayerst, Philadelphia, PA) is an immunoconjugate composed of recombinant humanized murine anti-CD33 antibody linked to calicheamicin, a potent cytotoxic agent. Phase II trials have sho...

journal_title：Current oncology reports

authors： Stadtmauer EA

更新日期：2002-09-01 00:00:00